2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N11641
    Methyl ganoderate A acetonide 1346453-53-9 98%
    Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent AChE inhibitor with an IC50 value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD).
    Methyl ganoderate A acetonide
  • HY-N11872
    Suffruticosol A 98%
    Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora.
    Suffruticosol A
  • HY-N11922
    Ipalbidine 26294-41-7 98%
    Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects.
    Ipalbidine
  • HY-N11930
    5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone 357637-15-1 98%
    Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent. Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell.
    5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone
  • HY-N11972
    β-Maaliene 489-29-2 98%
    β-Maaliene can be isolated from the fresh leaves of Vitex densiflora (Maaliene) and is the main component in the isolate. β-Maaliene can significantly reduce the exercise capacity of mice at certain doses.
    β-Maaliene
  • HY-N11997
    Feralolide 149418-38-2 98%
    Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory.
    Feralolide
  • HY-N12018
    Isomaltopaeoniflorin 262350-54-9 98%
    Isomaltopaeoniflorin is a metabolite of the Chinese herbal formula Shuyu. Shuyu is a depression-like disease inhibitor.
    Isomaltopaeoniflorin
  • HY-N12027
    AChE/BChE-IN-14 98%
    AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research.
    AChE/BChE-IN-14
  • HY-N12038
    Coumarinic acid 495-79-4 98%
    Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. Coumarinic acid can be used in study anti-Alzheimer drug.
    Coumarinic acid
  • HY-N12075
    Dehydrodiscretamine chloride 78134-82-4 98%
    Dehydrodiscretamine chloride is a dual inhibitor of AChE and BChE with IC50s of 17.8 and 118.8 μM, respectively. Dehydrodiscretamine chloride has antioxidant activity. Dehydrodiscretamine chloride can be used in study Alzheimer’s disease.
    Dehydrodiscretamine chloride
  • HY-N12100
    Gonyautoxin I 60748-39-2 98%
    Gonyautoxin I (GTX1) is a neurotoxin that can be isolated from Paralytic shellfish.
    Gonyautoxin I
  • HY-N12122
    Dehydropipernonaline 107584-38-3 98%
    Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC508.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .
    Dehydropipernonaline
  • HY-N12134
    Methyl piperate 6190-46-1 98%
    Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC503.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC5027.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to treat mental disorders .
    Methyl piperate
  • HY-N12170
    Kissoone C 903559-03-5 98%
    Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells.
    Kissoone C
  • HY-N12225
    Isoasiaticoside 948827-09-6 98%
    Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model.
    Isoasiaticoside
  • HY-N12249
    7-Deoxy-trans-dihydronarciclasine 145987-74-2 98%
    7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC50: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice.
    7-Deoxy-trans-dihydronarciclasine
  • HY-N12388
    AChE-IN-46 98%
    AChE-IN-46 (compound 4), a β-cyclocostunolide, is an AChE inhibitor.
    AChE-IN-46
  • HY-N12395
    Parishin G 952283-93-1 98%
    Parishin G is a Parishin (HY-N2031) derivative that can be isolated from Gastrodia elata. Parishin G has antioxidant activity.
    Parishin G
  • HY-N12398
    Psychotridine 52617-25-1 98%
    Psychotridine is a natural alkaloid isolated from Psychotria colorata, reveals an analgesic activity in nervous system and an inhibitory efficacy towards platelet aggregation.
    Psychotridine
  • HY-N12423
    Bis-(-)-8-demethylmaritidine 98%
    Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research.
    Bis-(-)-8-demethylmaritidine
Cat. No. Product Name / Synonyms Application Reactivity